Melanotan II
MT-II
A Melanocortin Peptide for Pigmentation —
Clinical Considerations
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Overview
Melanotan II is a synthetic analogue of alpha-melanocyte–stimulating hormone (α-MSH) that activates melanocortin receptors to increase melanin production. It has been used in non-regulated settings for skin tanning and pigmentation enhancement.
Observed Effects / Uses
Appetite suppression and libido effects (off-target CNS activity)
Darkening of existing nevi and development of new pigmented lesions
Increased skin pigmentation (“sunless tanning”)
Clinical Rationale
Melanotan II exerts biologic effects through:
Stimulation of melanogenesis independent of UV exposure
Activation of melanocortin- 1 receptors (MC1R) → increased melanin synthesis
Nonselective melanocortin receptor activity affecting appetite, libido, and systemic pathways
Administration
Commonly self-administered via subcutaneous injection in non-medical settings. There are no standardized, clinically validated dosing protocols.
This information is provided for educational purposes and reflects a general overview of studied biologic mechanisms. Statements have not been evaluated by the FDA. Individual protocols, appropriateness, and outcomes are determined on a case-by-case basis following clinical evaluation. Individual results may vary.